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TargetCytochrome P450 2D6 (2D6)
LigandBDBM50377223
Substrate/Competitorn/a
Meas. Tech.ChEMBL_479363
IC50 3700±n/a nM
Citation McAtee JJDodson JWDowdell SEGirard GRGoodman KBHilfiker MASehon CASha DWang GZWang NViet AQZhang DAiyar NVBehm DJCarballo LHEvans CAFries HENagilla RRoethke TJXu XYuan CCDouglas SANeeb MJ Development of potent and selective small-molecule human Urotensin-II antagonists. Bioorg Med Chem Lett 18:3500-3 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6 (2D6)
Name:Cytochrome P450 2D6
Synonyms:CYPIID6 | Cytochrome P450 2D6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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  Blast E-value cutoff:
BDBM50377223
n/a
NameBDBM50377223
Synonyms:CHEMBL258251
TypeSmall organic molecule
Emp. Form.C26H30Cl2N4O2
Mol. Mass.501.448
SMILESClc1ccc(cc1Cl)N(CC#N)CC(=O)N1CCCC(C1CN1CCOCC1)c1ccccc1 |w:19.30,20.22|
Structure
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