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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glycogen synthase kinase-3 alpha | ||
| Ligand | BDBM50377238 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_479409 (CHEMBL928211) | ||
| IC50 | 123±n/a nM | ||
| Citation |  Lum, C; Kahl, J; Kessler, L; Kucharski, J; Lundström, J; Miller, S; Nakanishi, H; Pei, Y; Pryor, K; Roberts, E; Sebo, L; Sullivan, R; Urban, J; Wang, Z 2,5-Diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3). Bioorg Med Chem Lett18:3578-81 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glycogen synthase kinase-3 alpha | |||
| Name: | Glycogen synthase kinase-3 alpha | ||
| Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50991.79 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P49840 | ||
| Residue: | 483 | ||
| Sequence: |
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| BDBM50377238 | |||
| n/a | |||
| Name | BDBM50377238 | ||
| Synonyms: | CHEMBL255948 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H18N6O | ||
| Mol. Mass. | 310.3537 | ||
| SMILES | O[C@H]1CC[C@@H](CC1)Nc1ncc2nnn(-c3ccccc3)c2n1 |wU:4.7,wD:1.0,(22.09,-29.69,;22.09,-28.15,;23.43,-27.38,;23.43,-25.84,;22.1,-25.08,;20.76,-25.84,;20.76,-27.38,;22.09,-23.54,;20.76,-22.77,;20.75,-21.21,;19.41,-20.45,;18.08,-21.23,;16.61,-20.76,;15.71,-22.01,;16.62,-23.25,;16.15,-24.71,;14.64,-25.03,;14.17,-26.5,;15.21,-27.64,;16.72,-27.31,;17.19,-25.84,;18.09,-22.77,;19.42,-23.54,)| | ||
| Structure | 
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