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TargetProbable flavin-dependent thymidylate synthase
LigandBDBM50377323
Substrate/Competitorn/a
Meas. Tech.ChEMBL_479520 (CHEMBL924875)
Ki 130±n/a nM
Citation Esra Onen, FBoum, YJacquement, CSpanedda, MVJaber, NScherman, DMyllykallio, HHerscovici, J Design, synthesis and evaluation of potent thymidylate synthase X inhibitors. Bioorg Med Chem Lett18:3628-31 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Probable flavin-dependent thymidylate synthase
Name:Probable flavin-dependent thymidylate synthase
Synonyms:Probable thymidylate synthase | THYX_PBCV1 | TS | TSase
Type:PROTEIN
Mol. Mass.:24907.10
Organism:Paramecium bursaria Chlorella virus 1
Description:ChEMBL_479520
Residue:216
Sequence:
MSAKLISVTKPVVEGVNTAEELIAYAARVSNPENQINNKTASGLLKYCIRHKHWSIFETA
FMTLELKTSRGIAAQVLRHRSFHFQEFSQRYASVMETPPPHQARFQDHKNRQNSLDTVPE
DDQTWWATEQEKLYAQSMELYNKALEKGIAKECARFILPLSTPTTIYMSGTIRDWIHYIE
LRTSNGTQREHIDLANACKEIFIKEFPSIAKALDWV
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  Blast E-value cutoff:
BDBM50377323
n/a
NameBDBM50377323
Synonyms:CHEMBL255717
TypeSmall organic molecule
Emp. Form.C26H32N2O4S
Mol. Mass.468.608
SMILESCCCCCCC(=O)N(C[C@@H]1CSC(N1C(=O)c1ccccc1)c1ccccc1)CC(O)=O |w:13.24|
Structure
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