| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50328717 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_479811 (CHEMBL930381) |
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| Ki | 0.057±n/a nM |
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| Citation |  Corte, JR; Fang, T; Pinto, DJ; Han, W; Hu, Z; Jiang, XJ; Li, YL; Gauuan, JF; Hadden, M; Orton, D; Rendina, AR; Luettgen, JM; Wong, PC; He, K; Morin, PE; Chang, CH; Cheney, DL; Knabb, RM; Wexler, RR; Lam, PY Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties. Bioorg Med Chem Lett18:2845-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50328717 |
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| n/a |
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| Name | BDBM50328717 |
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| Synonyms: | 5-Chloro-N-(5-chloro-pyridin-2-yl)-3-methoxy-2-[4-(2-oxo-piperidin-1-yl)-benzoylamino]-benzamide | 5-chloro-N-(5-chloropyridin-2-yl)-3-methoxy-2-(4-(2-oxopiperidin-1-yl)benzamido)benzamide | CHEMBL260085 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22Cl2N4O4 |
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| Mol. Mass. | 513.373 |
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| SMILES | COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1ccc(cc1)N1CCCCC1=O |
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| Structure | 
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