| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50377735 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_479968 (CHEMBL932361) |
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| IC50 | 0.98±n/a nM |
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| Citation |  Aster, SD; Graham, DW; Kharbanda, D; Patel, G; Ponpipom, M; Santorelli, GM; Szymonifka, MJ; Mundt, SS; Shah, K; Springer, MS; Thieringer, R; Hermanowski-Vosatka, A; Wright, SD; Xiao, J; Zokian, H; Balkovec, JM Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett18:2799-804 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32409.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28845 |
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| Residue: | 292 |
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| Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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| BDBM50377735 |
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| n/a |
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| Name | BDBM50377735 |
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| Synonyms: | CHEMBL257779 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15F3N4 |
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| Mol. Mass. | 356.3444 |
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| SMILES | Cn1c(nnc1-c1cccc2n(C)ccc12)-c1ccccc1C(F)(F)F |
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| Structure | 
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