| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| Ligand | BDBM50065997 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_502462 (CHEMBL986635) |
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| IC50 | 3100±n/a nM |
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| Citation |  Amagata, T; Whitman, S; Johnson, TA; Stessman, CC; Loo, CP; Lobkovsky, E; Clardy, J; Crews, P; Holman, TR Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod66:230-5 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| Synonyms: | 12-LOX | 12-Lipoxygenase (12-LOX) | 12LO | ALOX12 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | LOX12_HUMAN | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12 |
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| Type: | Protein |
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| Mol. Mass.: | 75689.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18054 |
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| Residue: | 663 |
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| Sequence: | MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL
QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA
LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA
GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML
LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL
VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH
LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST
GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH
LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH
AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR
QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS
VTI
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| BDBM50065997 |
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| n/a |
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| Name | BDBM50065997 |
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| Synonyms: | 5-[4-(3-hydroxy-4-methoxyphenyl)-2,3-dimethyl-(2R,3S)-butyl]-2-methoxyphenol | CHEMBL103600 | dimethylnordihydroguarierate acid |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26O4 |
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| Mol. Mass. | 330.418 |
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| SMILES | COc1ccc(C[C@H](C)[C@H](C)Cc2ccc(OC)c(O)c2)cc1O |r| |
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| Structure | 
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