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TargetCannabinoid receptor 1
LigandBDBM50260717
Substrate/Competitorn/a
Meas. Tech.ChEMBL_556337
Ki 1.75±n/a nM
Citation Wustrow DJMaynard GDYuan JZhao HMao JGuo QKershaw MHammer JBrodbeck RMNear KEZhou DBeers DSChenard BLKrause JEHutchison AJ Aminopyrazine CB1 receptor inverse agonists. Bioorg Med Chem Lett 18:3376-81 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM50260717
n/a
NameBDBM50260717
Synonyms:1-(6-(2,4-dichlorophenyl)-5-(4-fluorophenyl)pyrazin-2-yl)-4-(ethylamino)piperidine-4-carboxamide | CHEMBL496919
TypeSmall organic molecule
Emp. Form.C24H24Cl2FN5O
Mol. Mass.488.385
SMILESCCNC1(CCN(CC1)c1cnc(-c2ccc(F)cc2)c(n1)-c1ccc(Cl)cc1Cl)C(N)=O
Structure
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