| Reaction Details |
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 | Report a problem with these data |
| Target | Translocator protein |
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| Ligand | BDBM50255226 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_556775 (CHEMBL961473) |
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| Kd | 3.5±n/a nM |
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| Citation |  Yu, W; Wang, E; Voll, RJ; Miller, AH; Goodman, MM Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor. Bioorg Med Chem16:6145-55 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Translocator protein |
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| Name: | Translocator protein |
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| Synonyms: | BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 18834.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30536 |
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| Residue: | 169 |
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| Sequence: | MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAM
GYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAA
ATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
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| BDBM50255226 |
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| n/a |
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| Name | BDBM50255226 |
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| Synonyms: | (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide) | (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridozino[4,5-b]indole-1-acetamide) | CHEMBL517539 | SR-180575 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19ClN4O2 |
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| Mol. Mass. | 394.854 |
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| SMILES | CN(C)C(=O)Cc1nn(-c2ccccc2)c(=O)c2n(C)c3cc(Cl)ccc3c12 |
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| Structure | 
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