| Reaction Details |
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 | Report a problem with these data |
| Target | Pro-cathepsin H |
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| Ligand | BDBM50157741 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_508135 (CHEMBL1004872) |
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| IC50 | 190±n/a nM |
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| Citation |  Méthot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem282:20836-46 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pro-cathepsin H |
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| Name: | Pro-cathepsin H |
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| Synonyms: | CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37402.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1459870 |
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| Residue: | 335 |
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| Sequence: | MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS
NWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSV
DWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHG
CQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMV
EAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVK
NSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
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| BDBM50157741 |
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| n/a |
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| Name | BDBM50157741 |
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| Synonyms: | CHEMBL374508 | E-64 | E64 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H27N5O5 |
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| Mol. Mass. | 357.4054 |
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| SMILES | [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H]-1-[#8]-[#6@@H]-1-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r| |
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| Structure | 
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