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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 14 | ||
| Ligand | BDBM50251993 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_488009 (CHEMBL1013888) | ||
| IC50 | 3±n/a nM | ||
| Citation |  Laufer, SA; Hauser, DR; Domeyer, DM; Kinkel, K; Liedtke, AJ Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region. J Med Chem51:4122-49 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 14 | |||
| Name: | Mitogen-activated protein kinase 14 | ||
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 41286.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q16539 | ||
| Residue: | 360 | ||
| Sequence: |
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| BDBM50251993 | |||
| n/a | |||
| Name | BDBM50251993 | ||
| Synonyms: | CHEMBL481952 | trans-4-{4-[4-(4-Fluoro-phenyl)-3-(2-methoxy-ethyl)-2-methylsulfanyl-1H-imidazol-5-yl]-pyridin-2-ylamino}-cyclohexanol | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H29FN4O2S | ||
| Mol. Mass. | 456.576 | ||
| SMILES | COCCn1c(SC)nc(c1-c1ccnc(N[C@H]2CC[C@H](O)CC2)c1)-c1ccc(F)cc1 |r,wU:17.17,wD:20.21,(29.63,-2.28,;28.09,-2.28,;27.32,-.95,;25.78,-.95,;25.02,.38,;25.93,1.62,;27.47,1.61,;28.24,.28,;25.03,2.87,;23.56,2.4,;23.56,.85,;22.23,.09,;20.9,.86,;19.56,.09,;19.56,-1.45,;20.91,-2.22,;20.91,-3.76,;22.25,-4.52,;23.58,-3.75,;24.93,-4.52,;24.93,-6.07,;26.26,-6.84,;23.59,-6.84,;22.25,-6.05,;22.23,-1.44,;22.24,3.17,;22.25,4.71,;20.92,5.49,;19.58,4.73,;18.25,5.51,;19.58,3.18,;20.91,2.41,)| | ||
| Structure | 
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