| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-3 |
|---|
| Ligand | BDBM50263094 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_489290 (CHEMBL990846) |
|---|
| Ki | 3.02±n/a nM |
|---|
| Citation |  Gao, Y; Kuwabara, H; Spivak, CE; Xiao, Y; Kellar, K; Ravert, HT; Kumar, A; Alexander, M; Hilton, J; Wong, DF; Dannals, RF; Horti, AG Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties. J Med Chem51:4751-64 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuronal acetylcholine receptor subunit alpha-3 |
|---|
| Name: | Neuronal acetylcholine receptor subunit alpha-3 |
|---|
| Synonyms: | ACHA3_RAT | Acra3 | Chrna3 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56995.52 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P04757 |
|---|
| Residue: | 499 |
|---|
| Sequence: | MGVVLLPPPLSMLMLVLMLLPAASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEV
SMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNN
ADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAK
IDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTI
NLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGE
YLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSGEGDT
PKTRTFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSE
SVNAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILV
CILGTAGLFLQPLMARDDT
|
|
|
|---|
| BDBM50263094 |
|---|
| n/a |
|---|
| Name | BDBM50263094 |
|---|
| Synonyms: | (S)-3-(azetidin-2-ylmethoxy)-2-[18F]fluoropyridine | CHEMBL449437 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H11FN2O |
|---|
| Mol. Mass. | 182.1948 |
|---|
| SMILES | Fc1ncccc1OC[C@@H]1CCN1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
