Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetNeuronal acetylcholine receptor subunit alpha-3
LigandBDBM50263171
Substrate/Competitorn/a
Meas. Tech.ChEMBL_489290 (CHEMBL990846)
Ki 0.093±n/a nM
Citation Gao, YKuwabara, HSpivak, CEXiao, YKellar, KRavert, HTKumar, AAlexander, MHilton, JWong, DFDannals, RFHorti, AG Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties. J Med Chem51:4751-64 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuronal acetylcholine receptor subunit alpha-3
Name:Neuronal acetylcholine receptor subunit alpha-3
Synonyms:ACHA3_RAT | Acra3 | Chrna3
Type:Enzyme
Mol. Mass.:56995.52
Organism:Rattus norvegicus (Rat)
Description:P04757
Residue:499
Sequence:
MGVVLLPPPLSMLMLVLMLLPAASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEV
SMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNN
ADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAK
IDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTI
NLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGE
YLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSGEGDT
PKTRTFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSE
SVNAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILV
CILGTAGLFLQPLMARDDT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50263171
n/a
NameBDBM50263171
Synonyms:(+)-2-(6'-[18F]fluoro-3,3'-bipyridin-5-yl)-7-methyl-7-azabicyclo[2.2.1]heptane | (-)-2-(6'-fluoro-3,3'-bipyridin-5-yl)-7-methyl-7-azabicyclo[2.2.1]heptane | CHEMBL478029
TypeSmall organic molecule
Emp. Form.C17H18FN3
Mol. Mass.283.3433
SMILESCN1C2CCC1C(C2)c1cncc(c1)-c1ccc(F)nc1 |TLB:8:6:3.4:1|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: