| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-6 |
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| Ligand | BDBM50263171 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_489293 (CHEMBL990849) |
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| Ki | 0.047±n/a nM |
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| Citation |  Gao, Y; Kuwabara, H; Spivak, CE; Xiao, Y; Kellar, K; Ravert, HT; Kumar, A; Alexander, M; Hilton, J; Wong, DF; Dannals, RF; Horti, AG Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties. J Med Chem51:4751-64 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-6 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-6 |
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| Synonyms: | ACHA6_RAT | Acra6 | Chrna6 | Neuronal acetylcholine receptor protein alpha-6 subunit | Neuronal acetylcholine receptor subunit alpha-6 | Neuronal acetylcholine receptor subunit alpha-6/beta-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56943.53 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1454451 |
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| Residue: | 493 |
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| Sequence: | MLNGWGRGDLRSGLCLWICGFLAFFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVT
VHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDI
VLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWT
YDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLP
MFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVI
PLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLD
KTKEMDGVKDPKTHTKRPAKVKFTHRKEPKLLKECRHCHKSSEIAPGKRLSQQPAQWVTE
NSEHPPDVEDVIDSVQFIAENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVG
LFLQPLLGNTGAS
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| BDBM50263171 |
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| n/a |
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| Name | BDBM50263171 |
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| Synonyms: | (+)-2-(6'-[18F]fluoro-3,3'-bipyridin-5-yl)-7-methyl-7-azabicyclo[2.2.1]heptane | (-)-2-(6'-fluoro-3,3'-bipyridin-5-yl)-7-methyl-7-azabicyclo[2.2.1]heptane | CHEMBL478029 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18FN3 |
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| Mol. Mass. | 283.3433 |
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| SMILES | CN1C2CCC1C(C2)c1cncc(c1)-c1ccc(F)nc1 |TLB:8:6:3.4:1| |
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| Structure | 
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