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TargetNeuronal acetylcholine receptor subunit alpha-6
LigandBDBM50263095
Substrate/Competitorn/a
Meas. Tech.ChEMBL_489293 (CHEMBL990849)
Ki 0.031±n/a nM
Citation Gao, YKuwabara, HSpivak, CEXiao, YKellar, KRavert, HTKumar, AAlexander, MHilton, JWong, DFDannals, RFHorti, AG Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties. J Med Chem51:4751-64 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuronal acetylcholine receptor subunit alpha-6
Name:Neuronal acetylcholine receptor subunit alpha-6
Synonyms:ACHA6_RAT | Acra6 | Chrna6 | Neuronal acetylcholine receptor protein alpha-6 subunit | Neuronal acetylcholine receptor subunit alpha-6 | Neuronal acetylcholine receptor subunit alpha-6/beta-3
Type:PROTEIN
Mol. Mass.:56943.53
Organism:Rattus norvegicus
Description:ChEMBL_1454451
Residue:493
Sequence:
MLNGWGRGDLRSGLCLWICGFLAFFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVT
VHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDI
VLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWT
YDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLP
MFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVI
PLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLD
KTKEMDGVKDPKTHTKRPAKVKFTHRKEPKLLKECRHCHKSSEIAPGKRLSQQPAQWVTE
NSEHPPDVEDVIDSVQFIAENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVG
LFLQPLLGNTGAS
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  Blast E-value cutoff:
BDBM50263095
n/a
NameBDBM50263095
Synonyms:(+)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane | (+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane | (-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane | CHEMBL514372
TypeSmall organic molecule
Emp. Form.C17H18FN3
Mol. Mass.283.3433
SMILESCN1[C@@H]2CC[C@@H]1[C@H](C2)c1cncc(c1)-c1ccnc(F)c1 |r,TLB:8:6:3.4:1|
Structure
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