| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| Ligand | BDBM23419 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_555026 (CHEMBL958789) |
|---|
| IC50 | 14400±n/a nM |
|---|
| Citation |  Schuster, D; Nashev, LG; Kirchmair, J; Laggner, C; Wolber, G; Langer, T; Odermatt, A Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. J Med Chem51:4188-99 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 17-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| Name: | 17-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| Synonyms: | 17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase |
|---|
| Type: | Oxidoreductase; single-pass type II membrane protein |
|---|
| Mol. Mass.: | 42795.29 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Enzyme was partially purified from human placenta. |
|---|
| Residue: | 387 |
|---|
| Sequence: | MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
YFAKRHFGQDKPMPRALRMPNYKKKAT
|
|
|
|---|
| BDBM23419 |
|---|
| n/a |
|---|
| Name | BDBM23419 |
|---|
| Synonyms: | (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one | CHEMBL9352 | Naringenin |
|---|
| Type | flavanone |
|---|
| Emp. Form. | C15H12O5 |
|---|
| Mol. Mass. | 272.2528 |
|---|
| SMILES | Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
