| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM50243345 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_487377 (CHEMBL1021904) |
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| Ki | 2.10±n/a nM |
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| Citation |  Su, DS; Lim, JL; Tinney, E; Wan, BL; Murphy, KL; Reiss, DR; Harrell, CM; O'Malley, SS; Ransom, RW; Chang, RS; Pettibone, DJ; Yu, J; Tang, C; Prueksaritanont, T; Freidinger, RM; Bock, MG; Anthony, NJ 2-Aminobenzophenones as a novel class of bradykinin B1 receptor antagonists. J Med Chem51:3946-52 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40508.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46663 |
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| Residue: | 353 |
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| Sequence: | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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| BDBM50243345 |
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| n/a |
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| Name | BDBM50243345 |
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| Synonyms: | CHEMBL451761 | Tetrahydrofuran-2-ylmethyl{4-[({2-[(5-fluoropyridin-2-yl)carbonyl]phenyl}amino)sulfonyl]phenyl}carbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22FN3O6S |
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| Mol. Mass. | 499.511 |
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| SMILES | Fc1ccc(nc1)C(=O)c1ccccc1NS(=O)(=O)c1ccc(NC(=O)OCC2CCCO2)cc1 |
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| Structure | 
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