| Reaction Details |
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 | Report a problem with these data |
| Target | Small conductance calcium-activated potassium channel protein 1 |
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| Ligand | BDBM50263327 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_535548 (CHEMBL986174) |
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| IC50 | 4±n/a nM |
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| Citation |  Gentles, RG; Grant-Young, K; Hu, S; Huang, Y; Poss, MA; Andres, C; Fiedler, T; Knox, R; Lodge, N; Weaver, CD; Harden, DG Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels. Bioorg Med Chem Lett18:5316-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Small conductance calcium-activated potassium channel protein 1 |
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| Name: | Small conductance calcium-activated potassium channel protein 1 |
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| Synonyms: | KCNN1 | KCNN1_HUMAN | SK | Small conductance calcium-activated potassium channel protein 1 | Small conductance calcium-activated potassium channel protein 1 (KCa2.1) |
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| Type: | Protein |
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| Mol. Mass.: | 60005.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92952 |
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| Residue: | 543 |
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| Sequence: | MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPR
GQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVV
MVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIA
MTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYL
LGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWT
VRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTAL
VVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARV
RKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEA
RLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPS
DCG
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| BDBM50263327 |
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| n/a |
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| Name | BDBM50263327 |
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| Synonyms: | CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C14H12N4S |
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| Mol. Mass. | 268.337 |
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| SMILES | Cc1ccnc(Nc2nc(cs2)-c2ccccn2)c1 |
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| Structure | 
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