| Reaction Details |
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 | Report a problem with these data |
| Target | Amyloid-beta precursor protein |
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| Ligand | BDBM50264047 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_535894 (CHEMBL983535) |
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| IC50 | 160±n/a nM |
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| Citation |  Byun, JH; Kim, H; Kim, Y; Mook-Jung, I; Kim, DJ; Lee, WK; Yoo, KH Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation. Bioorg Med Chem Lett18:5591-3 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amyloid-beta precursor protein |
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| Name: | Amyloid-beta precursor protein |
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| Synonyms: | A4 | A4_HUMAN | ABPP | AD1 | AICD-50 | AICD-57 | AICD-59 | AID(50) | AID(57) | AID(59) | APP | APPI | Alzheimer disease amyloid protein | Amyloid beta A4 protein | Amyloid beta Protein | Amyloid beta protein (sAPPbeta) | Amyloid beta protein Abeta(1-42) | Amyloid intracellular domain 50 | Amyloid intracellular domain 57 | Amyloid intracellular domain 59 | Amyloid protein (Abeta42b) | Amyloid β-protein (Aβ42) | Beta amyloid A4 protein | Beta-APP40 | Beta-APP42 | Beta-amyloid protein 40 | Beta-amyloid protein 42 | C31 | C83 | C99 | CVAP | Cerebral vascular amyloid peptide | Gamma Secretase | Gamma-CTF(50) | Gamma-CTF(57) | Gamma-CTF(59) | Gamma-secretase | Gamma-secretase C-terminal fragment 50 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | P3(40) | P3(42) | PN-II | PreA4 | Protease nexin-II | S-APP-alpha | S-APP-beta | Soluble APP-alpha | Soluble APP-beta | beta-Amyloid Precursor Protein (APP) |
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| Type: | Single-pass type I membrane protein |
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| Mol. Mass.: | 86890.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05067 |
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| Residue: | 770 |
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| Sequence: | MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
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| BDBM50264047 |
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| n/a |
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| Name | BDBM50264047 |
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| Synonyms: | 2-methoxy-4-(2-(5-methoxybenzofuran-2-yl)vinyl)-N,N-dimethylbenzenamine | CHEMBL489792 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21NO3 |
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| Mol. Mass. | 323.3856 |
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| SMILES | COc1ccc2oc(\C=C\c3ccc(N(C)C)c(OC)c3)cc2c1 |
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| Structure | 
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