| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50274774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_537686 (CHEMBL993480) |
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| IC50 | 25±n/a nM |
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| Citation |  Kawai, K; Hayakawa, J; Miyamoto, T; Imamura, Y; Yamane, S; Wakita, H; Fujii, H; Kawamura, K; Matsuura, H; Izumimoto, N; Kobayashi, R; Endo, T; Nagase, H Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. Bioorg Med Chem16:9188-201 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | KOR-1 | MSL-1 | OPIATE Kappa | OPRK_MOUSE | Oprk1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42656.78 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P33534 |
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| Residue: | 380 |
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| Sequence: | MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV
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| BDBM50274774 |
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| n/a |
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| Name | BDBM50274774 |
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| Synonyms: | CHEMBL456659 | N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-hexanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H36N2O4 |
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| Mol. Mass. | 440.575 |
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| SMILES | CCCCCC(=O)N[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CC1)c45 |r,TLB:10:11:15.31.14:24.26.25,THB:12:11:15.31.14:24.26.25| |
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| Structure | 
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