Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50274258 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_537932 (CHEMBL983517) |
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Ki | 0.31±n/a nM |
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Citation | Denora, N; Laquintana, V; Pisu, MG; Dore, R; Murru, L; Latrofa, A; Trapani, G; Sanna, E 2-Phenyl-imidazo[1,2-a]pyridine compounds containing hydrophilic groups as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity and electrophysiological studies. J Med Chem51:6876-88 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50274258 |
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n/a |
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Name | BDBM50274258 |
Synonyms: | 2-(6,8-Dichloro-2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide | CHEMBL509917 |
Type | Small organic molecule |
Emp. Form. | C22H25Cl2N3O2 |
Mol. Mass. | 434.359 |
SMILES | CCCN(CCC)C(=O)Cc1c(nc2c(Cl)cc(Cl)cn12)-c1ccc(OC)cc1 |
Structure |
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