Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50274562 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_537932 (CHEMBL983517) |
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Ki | 1.44±n/a nM |
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Citation | Denora, N; Laquintana, V; Pisu, MG; Dore, R; Murru, L; Latrofa, A; Trapani, G; Sanna, E 2-Phenyl-imidazo[1,2-a]pyridine compounds containing hydrophilic groups as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity and electrophysiological studies. J Med Chem51:6876-88 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50274562 |
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n/a |
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Name | BDBM50274562 |
Synonyms: | 2-(6,8-dichloro-2-(thiazol-2-yl)H-imidazo[1,2-a]pyridin-3-yl)-N-methyl-N-phenylacetamide | CHEMBL521304 |
Type | Small organic molecule |
Emp. Form. | C19H14Cl2N4OS |
Mol. Mass. | 417.312 |
SMILES | CN(C(=O)Cc1c(nc2c(Cl)cc(Cl)cn12)-c1nccs1)c1ccccc1 |
Structure |
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