| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Diacylglycerol lipase-beta |
|---|
| Ligand | BDBM24567 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_557688 (CHEMBL962983) |
|---|
| IC50 | 60±n/a nM |
|---|
| Citation |  Hoover, HS; Blankman, JL; Niessen, S; Cravatt, BF Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. Bioorg Med Chem Lett18:5838-41 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Diacylglycerol lipase-beta |
|---|
| Name: | Diacylglycerol lipase-beta |
|---|
| Synonyms: | DAGLB | DGLB_HUMAN | Sn1-specific diacylglycerol lipase beta |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 73731.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_557688 |
|---|
| Residue: | 672 |
|---|
| Sequence: | MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLI
VLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVA
DGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQ
LLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLA
LLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPL
TGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLV
ALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLI
NDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQ
EYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNP
NNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQ
EEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVS
CPAQGVSSVDVA
|
|
|
|---|
| BDBM24567 |
|---|
| n/a |
|---|
| Name | BDBM24567 |
|---|
| Synonyms: | (2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate | CHEMBL175247 | Orlistat | THLP | Tetrahydrolipstatin | US9328123, Orlistat | Xenical |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H53NO5 |
|---|
| Mol. Mass. | 495.7348 |
|---|
| SMILES | CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
