| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50246592 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_557942 (CHEMBL963040) |
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| Ki | 7.9±n/a nM |
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| Citation |  Murkin, AS; Clinch, K; Mason, JM; Tyler, PC; Schramm, VL Immucillins in custom catalytic-site cavities. Bioorg Med Chem Lett18:5900-3 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50246592 |
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| n/a |
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| Name | BDBM50246592 |
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| Synonyms: | 5'-deoxy-4'-hydroxy-5'-methylthio-DADMe-ImmH | CHEMBL512051 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H18N4O3S |
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| Mol. Mass. | 310.372 |
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| SMILES | CSC[C@@]1(O)CN(Cc2c[nH]c3c2nc[nH]c3=O)C[C@@H]1O |r| |
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| Structure | 
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