| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50246593 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_557943 (CHEMBL963041) |
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| Ki | 0.0052±n/a nM |
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| Citation |  Murkin, AS; Clinch, K; Mason, JM; Tyler, PC; Schramm, VL Immucillins in custom catalytic-site cavities. Bioorg Med Chem Lett18:5900-3 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50246593 |
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| n/a |
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| Name | BDBM50246593 |
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| Synonyms: | 7-((1,3-dihydroxypropan-2-ylamino)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | 7-({[2-hydroxy-1-(hydroxymethyl)ethyl]amino}methyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL505564 | Immucillins, 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H14N4O3 |
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| Mol. Mass. | 238.2432 |
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| SMILES | OCC(CO)NCc1c[nH]c2c1nc[nH]c2=O |
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| Structure | 
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