| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Ligand | BDBM50245831 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_559691 (CHEMBL1010089) |
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| IC50 | 112±n/a nM |
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| Citation |  Alhamadsheh, MM; Waters, NC; Sachdeva, S; Lee, P; Reynolds, KA Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett18:6402-5 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Name: | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Synonyms: | β-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH) | 3-oxoacyl-[acyl-carrier-protein] synthase III | FABH_MYCTU | fabH |
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| Type: | Enzyme |
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| Mol. Mass.: | 34865.07 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | P9WNG3 |
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| Residue: | 335 |
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| Sequence: | MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDES
AASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSA
GCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETP
FQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRR
AMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMA
ELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
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| BDBM50245831 |
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| n/a |
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| Name | BDBM50245831 |
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| Synonyms: | 2-(p-tolylthio)naphthalene-1,4-dione | CHEMBL501551 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12O2S |
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| Mol. Mass. | 280.341 |
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| SMILES | Cc1ccc(SC2=CC(=O)c3ccccc3C2=O)cc1 |t:6| |
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| Structure | 
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