| Reaction Details |
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 | Report a problem with these data |
| Target | Transporter |
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| Ligand | BDBM50136674 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_559243 (CHEMBL1014662) |
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| Ki | 16±n/a nM |
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| Citation |  Manning, JR; Sexton, T; Childers, SR; Davies, HM 1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors. Bioorg Med Chem Lett19:58-61 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transporter |
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| Name: | Transporter |
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| Synonyms: | NE transporter | NET | Norepinephrine transporter(NET) |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 69236.90 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Q63380 |
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| Residue: | 617 |
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| Sequence: | MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWG
KEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAW
NSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFA
IFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHL
VAQRDVRQFQLRHWLAI
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| BDBM50136674 |
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| n/a |
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| Name | BDBM50136674 |
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| Synonyms: | (3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine | (3R)-N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine | (R)-duloxetine | CHEMBL336920 | LY248685 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19NOS |
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| Mol. Mass. | 297.415 |
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| SMILES | CNCC[C@@H](Oc1cccc2ccccc12)c1cccs1 |r| |
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| Structure | 
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