| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 26A1 |
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| Ligand | BDBM50253809 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_511280 (CHEMBL996935) |
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| IC50 | 1500±n/a nM |
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| Citation |  Gomaa, MS; Armstrong, JL; Bobillon, B; Veal, GJ; Brancale, A; Redfern, CP; Simons, C Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells. Bioorg Med Chem16:8301-13 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 26A1 |
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| Name: | Cytochrome P450 26A1 |
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| Synonyms: | CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 56216.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43174 |
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| Residue: | 497 |
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| Sequence: | MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM
VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL
GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE
VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR
NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG
GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI
KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM
LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV
YPVDNLPARFTHFHGEI
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| BDBM50253809 |
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| n/a |
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| Name | BDBM50253809 |
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| Synonyms: | Benzothiazol-2-yl-{4-[(5H-imidazol-1-yl)-phenylmethyl]-phenyl}-amine | CHEMBL460780 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18N4S |
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| Mol. Mass. | 382.481 |
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| SMILES | N(c1nc2ccccc2s1)c1ccc(cc1)C(c1ccccc1)n1ccnc1 |
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| Structure | 
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