| Reaction Details |
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 | Report a problem with these data |
| Target | Translocator protein |
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| Ligand | BDBM22041 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_511514 (CHEMBL980957) |
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| Ki | 0.5±n/a nM |
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| Citation |  Da Settimo, F; Simorini, F; Taliani, S; La Motta, C; Marini, AM; Salerno, S; Bellandi, M; Novellino, E; Greco, G; Cosimelli, B; Da Pozzo, E; Costa, B; Simola, N; Morelli, M; Martini, C Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis. J Med Chem51:5798-806 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Translocator protein |
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| Name: | Translocator protein |
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| Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
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| Type: | Mitochondrion membrane protein |
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| Mol. Mass.: | 18945.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
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| Residue: | 169 |
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| Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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| BDBM22041 |
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| n/a |
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| Name | BDBM22041 |
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| Synonyms: | 2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-N,N-dipropylacetamide | Alpidem | Ananxyl | CHEMBL54349 | S-800342 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23Cl2N3O |
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| Mol. Mass. | 404.333 |
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| SMILES | CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1 |
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| Structure | 
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