| Reaction Details |
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 | Report a problem with these data |
| Target | Translocator protein |
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| Ligand | BDBM50253678 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_511514 (CHEMBL980957) |
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| Ki | 1.9±n/a nM |
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| Citation |  Da Settimo, F; Simorini, F; Taliani, S; La Motta, C; Marini, AM; Salerno, S; Bellandi, M; Novellino, E; Greco, G; Cosimelli, B; Da Pozzo, E; Costa, B; Simola, N; Morelli, M; Martini, C Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis. J Med Chem51:5798-806 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Translocator protein |
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| Name: | Translocator protein |
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| Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
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| Type: | Mitochondrion membrane protein |
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| Mol. Mass.: | 18945.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
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| Residue: | 169 |
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| Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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| BDBM50253678 |
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| n/a |
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| Name | BDBM50253678 |
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| Synonyms: | CHEMBL459945 | N,N-dihexyl-2-(7-methyl-2-phenyl-1H-indol-3-yl)-2-oxoacetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C29H38N2O2 |
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| Mol. Mass. | 446.6242 |
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| SMILES | CCCCCCN(CCCCCC)C(=O)C(=O)c1c([nH]c2c(C)cccc12)-c1ccccc1 |
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| Structure | 
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