Reaction Details |
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Target | DNA polymerase beta |
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Ligand | BDBM50253141 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_539183 (CHEMBL1024687) |
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Ki | 600±n/a nM |
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Citation | Liang, F; Jain, N; Hutchens, T; Shock, DD; Beard, WA; Wilson, SH; Chiarelli, MP; Cho, BP Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT. J Med Chem51:6460-70 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA polymerase beta |
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Name: | DNA polymerase beta |
Synonyms: | DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB |
Type: | Protein |
Mol. Mass.: | 38188.76 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 335 |
Sequence: | MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
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BDBM50253141 |
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n/a |
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Name | BDBM50253141 |
Synonyms: | [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl {[(phosphonatooxy)phosphinato]methyl}phosphonate |
Type | Small organic molecule |
Emp. Form. | C11H15N2O13P3 |
Mol. Mass. | 476.1659 |
SMILES | Cc1cn([C@H]2C[C@H](O)[C@@H](COP([O-])(=O)CP([O-])(=O)OP([O-])([O-])=O)O2)c(=O)[nH]c1=O |r| |
Structure |
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