| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase beta |
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| Ligand | BDBM50253100 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_539183 (CHEMBL1024687) |
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| Ki | 900±n/a nM |
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| Citation |  Liang, F; Jain, N; Hutchens, T; Shock, DD; Beard, WA; Wilson, SH; Chiarelli, MP; Cho, BP Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT. J Med Chem51:6460-70 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase beta |
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| Name: | DNA polymerase beta |
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| Synonyms: | DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB |
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| Type: | Protein |
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| Mol. Mass.: | 38188.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 335 |
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| Sequence: | MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
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| BDBM50253100 |
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| n/a |
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| Name | BDBM50253100 |
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| Synonyms: | [(2R,3S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl {[(phosphonatooxy)phosphinato]methyl}phosphonate |
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| Type | Small organic molecule |
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| Emp. Form. | C10H14N3O12P3 |
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| Mol. Mass. | 461.1545 |
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| SMILES | Nc1ccn([C@H]2C[C@H](O)[C@@H](COP([O-])(=O)CP([O-])(=O)OP([O-])([O-])=O)O2)c(=O)n1 |r| |
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| Structure | 
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