Reaction Details | |||
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Target | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | ||
Ligand | BDBM50274970 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_496150 (CHEMBL1000139) | ||
Ki | 7±n/a nM | ||
Citation | Berardi, F; Abate, C; Ferorelli, S; de Robertis, AF; Leopoldo, M; Colabufo, NA; Niso, M; Perrone, R Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. J Med Chem51:7523-31 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | |||
Name: | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | ||
Synonyms: | EBP | EBP_CAVPO | ||
Type: | PROTEIN | ||
Mol. Mass.: | 26684.52 | ||
Organism: | Cavia porcellus | ||
Description: | ChEMBL_203193 | ||
Residue: | 229 | ||
Sequence: |
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BDBM50274970 | |||
n/a | |||
Name | BDBM50274970 | ||
Synonyms: | CHEMBL513936 | trans-4-[4-(2,6-Dimethoxyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine | ||
Type | Small organic molecule | ||
Emp. Form. | C23H31N3O2 | ||
Mol. Mass. | 381.5111 | ||
SMILES | COc1cccc(OC)c1[C@H]1CC[C@@H](CC1)N1CCN(CC1)c1ccccn1 |r,wU:10.10,wD:13.17,(-7.45,-22.18,;-8.78,-22.95,;-8.77,-24.49,;-10.1,-25.26,;-10.1,-26.81,;-8.77,-27.58,;-7.43,-26.81,;-6.1,-27.57,;-6.1,-29.11,;-7.44,-25.26,;-6.11,-24.47,;-6.12,-22.94,;-4.78,-22.17,;-3.44,-22.94,;-3.45,-24.47,;-4.77,-25.24,;-2.12,-22.17,;-.78,-22.94,;.54,-22.18,;.55,-20.64,;-.78,-19.86,;-2.12,-20.63,;1.89,-19.87,;1.89,-18.34,;3.22,-17.57,;4.56,-18.35,;4.55,-19.89,;3.21,-20.65,)| | ||
Structure |