| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Motilin receptor |
|---|
| Ligand | BDBM50344942 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_495535 (CHEMBL1008005) |
|---|
| EC50 | 50.12±n/a nM |
|---|
| Citation |  Westaway, SM; Brown, SL; Fell, SC; Johnson, CN; MacPherson, DT; Mitchell, DJ; Myatt, JW; Stanway, SJ; Seal, JT; Stemp, G; Thompson, M; Lawless, K; McKay, F; Muir, AI; Barford, JM; Cluff, C; Mahmood, SR; Matthews, KL; Mohamed, S; Smith, B; Stevens, AJ; Bolton, VJ; Jarvie, EM; Sanger, GJ Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate. J Med Chem52:1180-9 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Motilin receptor |
|---|
| Name: | Motilin receptor |
|---|
| Synonyms: | G-protein coupled receptor 38 | GPR38 | MLNR | MTLR | MTLR1 | MTLR_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 45365.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_122664 |
|---|
| Residue: | 412 |
|---|
| Sequence: | MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTV
MLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEG
CTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVE
QDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPA
QLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVL
LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISK
KYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
|
|
|
|---|
| BDBM50344942 |
|---|
| n/a |
|---|
| Name | BDBM50344942 |
|---|
| Synonyms: | CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCIN ETHYLSUCCINATE | Erycette | Erymax | Erythromycin A | Erythromycin C | Ilotycin | T-Stat |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C37H67NO13 |
|---|
| Mol. Mass. | 733.9268 |
|---|
| SMILES | CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
