| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Ligand | BDBM50293021 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_518478 (CHEMBL938929) |
|---|
| IC50 | 858±n/a nM |
|---|
| Citation |  Kühnle, M; Egger, M; Müller, C; Mahringer, A; Bernhardt, G; Fricker, G; König, B; Buschauer, A Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar. J Med Chem52:1190-7 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Name: | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Synonyms: | ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter |
|---|
| Type: | Multi-pass membrane protein; monomer or homodimer; disulfide-linked |
|---|
| Mol. Mass.: | 72329.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UNQ0 |
|---|
| Residue: | 655 |
|---|
| Sequence: | MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
|
|
|
|---|
| BDBM50293021 |
|---|
| n/a |
|---|
| Name | BDBM50293021 |
|---|
| Synonyms: | CHEMBL506742 | N-(5-((4-(2-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)phenyl)aminocarbonyl)-2,3-dimethoxyphenyl)quinoline-3-carboxamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C38H38N4O6 |
|---|
| Mol. Mass. | 646.7315 |
|---|
| SMILES | COc1cc2CCN(CCc3ccc(NC(=O)c4cc(NC(=O)c5cnc6ccccc6c5)c(OC)c(OC)c4)cc3)Cc2cc1OC |
|---|
| Structure | 
|
|---|
Search and Browse
