Reaction Details |
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Target | Purine nucleoside phosphorylase |
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Ligand | BDBM50293086 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_519471 (CHEMBL951777) |
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Ki | 0.042±n/a nM |
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Citation | Clinch, K; Evans, GB; Fröhlich, RF; Furneaux, RH; Kelly, PM; Legentil, L; Murkin, AS; Li, L; Schramm, VL; Tyler, PC; Woolhouse, AD Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase. J Med Chem52:1126-43 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Purine nucleoside phosphorylase |
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Name: | Purine nucleoside phosphorylase |
Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
Type: | Enzyme |
Mol. Mass.: | 32119.53 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 289 |
Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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BDBM50293086 |
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n/a |
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Name | BDBM50293086 |
Synonyms: | (1S)-1,4-dideoxy-1,4-imino-1-(9-deazaguanin-9-yl)-D-ribitol | 1,4-DIDEOXY-1,4-IMINO-1-(S)-(9-DEAZAGUANIN-9-YL)-D-RIBITOL | 2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL473922 | immucillin G |
Type | Small organic molecule |
Emp. Form. | C11H15N5O4 |
Mol. Mass. | 281.2679 |
SMILES | Nc1nc2c(c[nH]c2c(=O)[nH]1)[C@@H]1N[C@H](CO)[C@@H](O)[C@H]1O |r| |
Structure |
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