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TargetPurine nucleoside phosphorylase
LigandBDBM50293086
Substrate/Competitorn/a
Meas. Tech.ChEMBL_519471 (CHEMBL951777)
Ki 0.042±n/a nM
Citation Clinch, KEvans, GBFröhlich, RFFurneaux, RHKelly, PMLegentil, LMurkin, ASLi, LSchramm, VLTyler, PCWoolhouse, AD Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase. J Med Chem52:1126-43 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Purine nucleoside phosphorylase
Name:Purine nucleoside phosphorylase
Synonyms:Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:Enzyme
Mol. Mass.:32119.53
Organism:Homo sapiens (Human)
Description:n/a
Residue:289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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  Blast E-value cutoff:
BDBM50293086
n/a
NameBDBM50293086
Synonyms:(1S)-1,4-dideoxy-1,4-imino-1-(9-deazaguanin-9-yl)-D-ribitol | 1,4-DIDEOXY-1,4-IMINO-1-(S)-(9-DEAZAGUANIN-9-YL)-D-RIBITOL | 2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL473922 | immucillin G
TypeSmall organic molecule
Emp. Form.C11H15N5O4
Mol. Mass.281.2679
SMILESNc1nc2c(c[nH]c2c(=O)[nH]1)[C@@H]1N[C@H](CO)[C@@H](O)[C@H]1O |r|
Structure
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