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TargetPurine nucleoside phosphorylase
LigandBDBM50293061
Substrate/Competitorn/a
Meas. Tech.ChEMBL_519471 (CHEMBL951777)
Ki 0.400±n/a nM
Citation Clinch, KEvans, GBFröhlich, RFFurneaux, RHKelly, PMLegentil, LMurkin, ASLi, LSchramm, VLTyler, PCWoolhouse, AD Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase. J Med Chem52:1126-43 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Purine nucleoside phosphorylase
Name:Purine nucleoside phosphorylase
Synonyms:Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:Enzyme
Mol. Mass.:32119.53
Organism:Homo sapiens (Human)
Description:n/a
Residue:289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50293061
n/a
NameBDBM50293061
Synonyms:2-Amino-7-({[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}methyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL489690
TypeSmall organic molecule
Emp. Form.C11H17N5O4
Mol. Mass.283.2838
SMILESNc1nc2c(CNC(CO)(CO)CO)c[nH]c2c(=O)[nH]1
Structure
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