| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50293082 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_519471 (CHEMBL951777) |
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| Ki | 190±n/a nM |
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| Citation |  Clinch, K; Evans, GB; Fröhlich, RF; Furneaux, RH; Kelly, PM; Legentil, L; Murkin, AS; Li, L; Schramm, VL; Tyler, PC; Woolhouse, AD Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase. J Med Chem52:1126-43 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50293082 |
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| n/a |
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| Name | BDBM50293082 |
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| Synonyms: | 7-({[(2S,3S,4R)-2,3,4,5-Tetrahydroxypentyl]amino}methyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL448606 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H18N4O5 |
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| Mol. Mass. | 298.2951 |
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| SMILES | OC[C@H](O)[C@H](O)[C@H](O)CNCc1c[nH]c2c1nc[nH]c2=O |r| |
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| Structure | 
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