| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 5B, mitochondrial |
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| Ligand | BDBM50256568 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_519587 (CHEMBL943662) |
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| Ki | 2700±n/a nM |
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| Citation |  Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. Bioorg Med Chem Lett18:6332-5 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 5B, mitochondrial |
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| Name: | Carbonic anhydrase 5B, mitochondrial |
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| Synonyms: | CA-VB | CA5B | CAH5B_HUMAN | Carbonate dehydratase VB | Carbonic Anhydrase VB | Carbonic anhydrase 5B (CA VB) | Carbonic anhydrase 5B, mitochondrial | Carbonic anhydrase 5B, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VB (CA VB) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36440.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human (cloned) isozyme |
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| Residue: | 317 |
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| Sequence: | MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPG
GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPL
EHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVI
GVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLS
ESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDY
VLNVQAKPKPATSQATP
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| BDBM50256568 |
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| n/a |
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| Name | BDBM50256568 |
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| Synonyms: | CHEMBL482150 | N-[5-(methylsulfonyl)-1,3,4-thiadiazol-2-yl]sulfamide |
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| Type | Small organic molecule |
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| Emp. Form. | C3H6N4O4S3 |
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| Mol. Mass. | 258.299 |
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| SMILES | CS(=O)(=O)c1nnc(NS(N)(=O)=O)s1 |
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| Structure | 
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