Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50275574 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_496821 (CHEMBL1008834) |
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IC50 | 120±n/a nM |
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Citation | Pescatore, G; Kinzel, O; Attenni, B; Cecchetti, O; Fiore, F; Fonsi, M; Rowley, M; Schultz-Fademrecht, C; Serafini, S; Steinkühler, C; Jones, P Optimization of a series of potent and selective ketone histone deacetylase inhibitors. Bioorg Med Chem Lett18:5528-32 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50275574 |
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n/a |
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Name | BDBM50275574 |
Synonyms: | (S)-N-(1-(5-(4-cyanophenyl)-1H-imidazol-2-yl)-7-oxooctyl)-1-methylpiperidine-4-carboxamide | CHEMBL487778 |
Type | Small organic molecule |
Emp. Form. | C25H33N5O2 |
Mol. Mass. | 435.5618 |
SMILES | CN1CCC(CC1)C(=O)N[C@@H](CCCCCC(C)=O)c1nc(c[nH]1)-c1ccc(cc1)C#N |r| |
Structure |
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