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TargetHistone deacetylase 8
LigandBDBM25146
Substrate/Competitorn/a
Meas. Tech.ChEMBL_496832 (CHEMBL1008845)
IC50>1±n/a nM
Citation Pescatore, GKinzel, OAttenni, BCecchetti, OFiore, FFonsi, MRowley, MSchultz-Fademrecht, CSerafini, SSteinkühler, CJones, P Optimization of a series of potent and selective ketone histone deacetylase inhibitors. Bioorg Med Chem Lett18:5528-32 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 8
Name:Histone deacetylase 8
Synonyms:HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:Enzyme
Mol. Mass.:41749.60
Organism:Homo sapiens (Human)
Description:Q9BY41
Residue:377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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  Blast E-value cutoff:
BDBM25146
n/a
NameBDBM25146
Synonyms:2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide | 4-phenylimidazole, 17 | CHEMBL407959
TypeSmall organic molecule
Emp. Form.C29H34N4O3
Mol. Mass.486.6053
SMILESCOc1ccc2[nH]c(C)c(CC(=O)N[C@@H](CCCCCC(C)=O)c3nc(c[nH]3)-c3ccccc3)c2c1 |r|
Structure
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