Reaction Details |
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Target | Histone deacetylase 8 |
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Ligand | BDBM25146 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_496832 (CHEMBL1008845) |
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IC50 | >1±n/a nM |
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Citation | Pescatore, G; Kinzel, O; Attenni, B; Cecchetti, O; Fiore, F; Fonsi, M; Rowley, M; Schultz-Fademrecht, C; Serafini, S; Steinkühler, C; Jones, P Optimization of a series of potent and selective ketone histone deacetylase inhibitors. Bioorg Med Chem Lett18:5528-32 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 8 |
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Name: | Histone deacetylase 8 |
Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
Type: | Enzyme |
Mol. Mass.: | 41749.60 |
Organism: | Homo sapiens (Human) |
Description: | Q9BY41 |
Residue: | 377 |
Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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BDBM25146 |
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n/a |
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Name | BDBM25146 |
Synonyms: | 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide | 4-phenylimidazole, 17 | CHEMBL407959 |
Type | Small organic molecule |
Emp. Form. | C29H34N4O3 |
Mol. Mass. | 486.6053 |
SMILES | COc1ccc2[nH]c(C)c(CC(=O)N[C@@H](CCCCCC(C)=O)c3nc(c[nH]3)-c3ccccc3)c2c1 |r| |
Structure |
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