Reaction Details |
| Report a problem with these data |
Target | Histone deacetylase 1 |
---|
Ligand | BDBM50276035 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_496821 (CHEMBL1008834) |
---|
IC50 | 160±n/a nM |
---|
Citation | Pescatore, G; Kinzel, O; Attenni, B; Cecchetti, O; Fiore, F; Fonsi, M; Rowley, M; Schultz-Fademrecht, C; Serafini, S; Steinkühler, C; Jones, P Optimization of a series of potent and selective ketone histone deacetylase inhibitors. Bioorg Med Chem Lett18:5528-32 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histone deacetylase 1 |
---|
Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
|
|
|
BDBM50276035 |
---|
n/a |
---|
Name | BDBM50276035 |
Synonyms: | (S)-3-cyano-N-(7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl)benzamide | CHEMBL470576 |
Type | Small organic molecule |
Emp. Form. | C25H26N4O2 |
Mol. Mass. | 414.4995 |
SMILES | CC(=O)CCCCC[C@H](NC(=O)c1cccc(c1)C#N)c1nc(c[nH]1)-c1ccccc1 |r| |
Structure |
|