Reaction Details |
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Target | Histamine H2 receptor |
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Ligand | BDBM50275884 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_493064 (CHEMBL953178) |
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EC50 | 6±n/a nM |
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Citation | Ghorai, P; Kraus, A; Keller, M; Götte, C; Igel, P; Schneider, E; Schnell, D; Bernhardt, G; Dove, S; Zabel, M; Elz, S; Seifert, R; Buschauer, A Acylguanidines as bioisosteres of guanidines: NG-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. J Med Chem51:7193-204 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H2 receptor |
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Name: | Histamine H2 receptor |
Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40567.22 |
Organism: | Cavia porcellus (domestic guinea pig) |
Description: | For the H2 receptor-binding assays, guinea pig striatum was used. |
Residue: | 359 |
Sequence: | MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSL
AVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYH
QLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
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BDBM50275884 |
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n/a |
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Name | BDBM50275884 |
Synonyms: | CHEMBL471413 | N1-(3,3-Diphenylpropanoyl)-N2-[3-(1H-imidazol-4-yl)propyl]guanidine |
Type | Small organic molecule |
Emp. Form. | C22H25N5O |
Mol. Mass. | 375.4668 |
SMILES | NC(NC(=O)CC(c1ccccc1)c1ccccc1)=NCCCc1cnc[nH]1 |w:19.21| |
Structure |
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