| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H2 receptor |
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| Ligand | BDBM50377986 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_493064 (CHEMBL953178) |
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| EC50 | 12±n/a nM |
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| Citation |  Ghorai, P; Kraus, A; Keller, M; Götte, C; Igel, P; Schneider, E; Schnell, D; Bernhardt, G; Dove, S; Zabel, M; Elz, S; Seifert, R; Buschauer, A Acylguanidines as bioisosteres of guanidines: NG-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. J Med Chem51:7193-204 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H2 receptor |
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| Name: | Histamine H2 receptor |
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| Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40567.22 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | For the H2 receptor-binding assays, guinea pig striatum was used. |
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| Residue: | 359 |
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| Sequence: | MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSL
AVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYH
QLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
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| BDBM50377986 |
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| n/a |
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| Name | BDBM50377986 |
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| Synonyms: | CHEMBL483406 | UR-AK24 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H23N5O |
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| Mol. Mass. | 313.3974 |
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| SMILES | CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1 |w:8.8| |
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| Structure | 
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