| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H1 receptor |
|---|
| Ligand | BDBM86742 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_493057 (CHEMBL953171) |
|---|
| Kd | 741.31±n/a nM |
|---|
| Citation |  Ghorai, P; Kraus, A; Keller, M; Götte, C; Igel, P; Schneider, E; Schnell, D; Bernhardt, G; Dove, S; Zabel, M; Elz, S; Seifert, R; Buschauer, A Acylguanidines as bioisosteres of guanidines: NG-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. J Med Chem51:7193-204 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H1 receptor |
|---|
| Name: | Histamine H1 receptor |
|---|
| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 55641.53 |
|---|
| Organism: | Cavia porcellus (domestic guinea pig) |
|---|
| Description: | Guinea pig cerebellum was used in binding assay. |
|---|
| Residue: | 488 |
|---|
| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
|
|
|
|---|
| BDBM86742 |
|---|
| n/a |
|---|
| Name | BDBM86742 |
|---|
| Synonyms: | UR-AK64 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H29N5O |
|---|
| Mol. Mass. | 319.4451 |
|---|
| SMILES | NC(NC(=O)CCCC1CCCCC1)=NCCCc1cnc[nH]1 |w:14.15| |
|---|
| Structure | 
|
|---|
Search and Browse
