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TargetTyrosine-protein kinase JAK1
LigandBDBM50227519
Substrate/Competitorn/a
Meas. Tech.ChEMBL_542085 (CHEMBL1016954)
IC50>10000±n/a nM
Citation Changelian, PSFlanagan, MEBall, DJKent, CRMagnuson, KSMartin, WHRizzuti, BJSawyer, PSPerry, BDBrissette, WHMcCurdy, SPKudlacz, EMConklyn, MJElliott, EAKoslov, ERFisher, MBStrelevitz, TJYoon, KWhipple, DASun, JMunchhof, MJDoty, JLCasavant, JMBlumenkopf, TAHines, MBrown, MFLillie, BMSubramanyam, CShang-Poa, CMilici, AJBeckius, GEMoyer, JDSu, CWoodworth, TGGaweco, ASBeals, CRLittman, BHFisher, DASmith, JFZagouras, PMagna, HASaltarelli, MJJohnson, KSNelms, LFDes Etages, SGHayes, LSKawabata, TTFinco-Kent, DBaker, DLLarson, MSi, MSPaniagua, RHiggins, JHolm, BReitz, BZhou, YJMorris, REO'Shea, JJBorie, DC Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science302:875-878 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase JAK1
Name:Tyrosine-protein kinase JAK1
Synonyms:JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1
Type:Protein
Mol. Mass.:133293.73
Organism:Homo sapiens (Human)
Description:P23458
Residue:1154
Sequence:
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA
IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS
DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT
SFQNLIEGFEALLK
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  Blast E-value cutoff:
BDBM50227519
n/a
NameBDBM50227519
Synonyms:4-(6,7-dimethoxyquinazolin-4-ylamino)phenol | CHEMBL405130 | CHEMBL555201 | US10548897, Compound 7 | WHI-P131
TypeSmall organic molecule
Emp. Form.C16H15N3O3
Mol. Mass.297.3086
SMILESCOc1cc2ncnc(Nc3ccc(O)cc3)c2cc1OC
Structure
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