| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 6 |
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| Ligand | BDBM10882 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_565860 (CHEMBL959283) |
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| Ki | 43±n/a nM |
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| Citation |  Crocetti, L; Maresca, A; Temperini, C; Hall, RA; Scozzafava, A; Mühlschlegel, FA; Supuran, CT A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg Med Chem Lett19:1371-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 6 |
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| Name: | Carbonic anhydrase 6 |
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| Synonyms: | CA-VI | CA6 | CAH6_HUMAN | Carbonate dehydratase VI | Carbonic Anhydrase VI | Carbonic anhydrase | Carbonic anhydrase 6 | Carbonic anhydrase 6 (CA VI) | Carbonic anhydrase 6 (CA-VI) | Carbonic anhydrase VI (CA VI) | Salivary carbonic anhydrase | Secreted carbonic anhydrase |
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| Type: | Enzyme |
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| Mol. Mass.: | 35371.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23280 |
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| Residue: | 308 |
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| Sequence: | MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYN
PSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSE
ISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNF
ISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLS
RTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEIL
DYLRRALN
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| BDBM10882 |
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| n/a |
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| Name | BDBM10882 |
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| Synonyms: | 6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL18 | Ethamide | Ethoxazolamide | Ethoxzolamide | Ethoxzolamide (EZA) | Ethoxzolamide, EZM | Sulfonamide, 3 | US10172837, Ethoxyzolamide | sulfonamide 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H10N2O3S2 |
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| Mol. Mass. | 258.317 |
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| SMILES | CCOc1ccc2nc(sc2c1)S(N)(=O)=O |
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| Structure | 
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