| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2C8 |
|---|
| Ligand | BDBM50134931 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_567198 (CHEMBL1029110) |
|---|
| IC50 | 13000±n/a nM |
|---|
| Citation |  O'Neill, PM; Shone, AE; Stanford, D; Nixon, G; Asadollahy, E; Park, BK; Maggs, JL; Roberts, P; Stocks, PA; Biagini, G; Bray, PG; Davies, J; Berry, N; Hall, C; Rimmer, K; Winstanley, PA; Hindley, S; Bambal, RB; Davis, CB; Bates, M; Gresham, SL; Brigandi, RA; Gomez-de-Las-Heras, FM; Gargallo, DV; Parapini, S; Vivas, L; Lander, H; Taramelli, D; Ward, SA Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable"back-up" compound for N-tert-butyl isoquine. J Med Chem52:1828-44 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2C8 |
|---|
| Name: | Cytochrome P450 2C8 |
|---|
| Synonyms: | CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55839.23 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10632 |
|---|
| Residue: | 490 |
|---|
| Sequence: | MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
|
|
|
|---|
| BDBM50134931 |
|---|
| n/a |
|---|
| Name | BDBM50134931 |
|---|
| Synonyms: | 5-(7-Chloro-quinolin-4-ylamino)-2-diethylaminomethyl-phenol | 5-(7-chloroquinolin-4-ylamino)-2-((diethylamino)methyl)phenol | CHEMBL147587 | isoquine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22ClN3O |
|---|
| Mol. Mass. | 355.861 |
|---|
| SMILES | CCN(CC)Cc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1O |
|---|
| Structure | 
|
|---|
Search and Browse
