Ki Summary

Reaction Details

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Target

Meiotic mRNA stability protein kinase SSN3

Ligand

BDBM50113707

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_563815 (CHEMBL994327)

IC50

>500000±n/a nM

Citation

Gray, NS; Wodicka, L; Thunnissen, AM; Norman, TC; Kwon, S; Espinoza, FH; Morgan, DO; Barnes, G; LeClerc, S; Meijer, L; Kim, SH; Lockhart, DJ; Schultz, PG Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science281:533-538 (1998) [PubMed]

More Info.:

Get all data from this article, Assay Method

Meiotic mRNA stability protein kinase SSN3

Name:

Meiotic mRNA stability protein kinase SSN3

Synonyms:

ARE1 | CDK8 | GIG2 | SRB10 | SSN3 | SSN3_YEAST | UME5

Type:

PROTEIN

Mol. Mass.:

62879.98

Organism:

Saccharomyces cerevisiae

Description:

ChEMBL_563815

Residue:

555

Sequence:

MYNGKDRAQNSYQPMYQRPMQVQGQQQAQSFVGKKNTIGSVHGKAPMLMANNDVFTIGPY
RARKDRMRVSVLEKYEVIGYIAAGTYGKVYKAKRQINSGTNSANGSSLNGTNAKIPQFDS
TQPKSSSSMDMQANTNALRRNLLKDEGVTPGRIRTTREDVSPHYNSQKQTLIKKPLTVFY
AIKKFKTEKDGVEQLHYTGISQSACREMALCRELHNKHLTTLVEIFLERKCVHMVYEYAE
HDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGCV
KIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELIG
LQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITKFPKYRD
NLATWYHSAGGRDKHALSLLYHLLNYDPIKRIDAFNALEHKYFTESDIPVSENVFEGLTY
KYPARRIHTNDNDIMNLGSRTKNNTQASGITAGAAANALGGLGVNRRILAAAAAAAAAVS
GNNASDEPSRKKNRR

BDBM50113707

n/a

Name

BDBM50113707

Synonyms:

2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | 2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-ethanol | CHEMBL311228

Type

Small organic molecule

Emp. Form.

C16H19ClN6O

Mol. Mass.

346.815

SMILES

CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(NCCO)nc12

Structure