| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase CAK1 |
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| Ligand | BDBM50113707 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_563816 (CHEMBL994328) |
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| IC50 | >500000±n/a nM |
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| Citation |  Gray, NS; Wodicka, L; Thunnissen, AM; Norman, TC; Kwon, S; Espinoza, FH; Morgan, DO; Barnes, G; LeClerc, S; Meijer, L; Kim, SH; Lockhart, DJ; Schultz, PG Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science281:533-538 (1998) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase CAK1 |
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| Name: | Serine/threonine-protein kinase CAK1 |
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| Synonyms: | CAK1 | CAK1_YEAST | CIV1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42181.94 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_563816 |
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| Residue: | 368 |
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| Sequence: | MKLDSIDITHCQLVKSTRTARIYRSDTYAIKCLALDFDIPPHNAKFEVSILNKLGNKCKH
ILPLLESKATDNNDLLLLFPFEEMNLYEFMQMHYKRDRRKKNPYYDLLNPSIPIVADPPV
QKYTNQLDVNRYSLSFFRQMVEGIAFLHENKIIHRDIKPQNIMLTNNTSTVSPKLYIIDF
GISYDMANNSQTSAEPMDSKVTDISTGIYKAPEVLFGVKCYDGGVDVWSLLIIISQWFQR
ETSRMGHVPAMIDDGSDDMNSDGSDFRLICSIFEKLGIPSIQKWEEVAQHGSVDAFVGMF
GADGDGKYVLDQEKDVQISIVERNMPRLDEIADVKVKQKFINCILGMVSFSPNERWSCQR
ILQELEKP
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| BDBM50113707 |
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| n/a |
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| Name | BDBM50113707 |
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| Synonyms: | 2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | 2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-ethanol | CHEMBL311228 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19ClN6O |
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| Mol. Mass. | 346.815 |
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| SMILES | CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(NCCO)nc12 |
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| Structure | 
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