Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50278387 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_564843 (CHEMBL955070) |
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Ki | 260±n/a nM |
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Citation | Wentland, MP; Lou, R; Lu, Q; Bu, Y; Denhardt, C; Jin, J; Ganorkar, R; VanAlstine, MA; Guo, C; Cohen, DJ; Bidlack, JM Syntheses of novel high affinity ligands for opioid receptors. Bioorg Med Chem Lett19:2289-94 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50278387 |
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n/a |
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Name | BDBM50278387 |
Synonyms: | (1S,5R,13R,17R)-4-methyl-14-oxo-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-triene-10-carboxamide | CHEMBL471049 |
Type | Small organic molecule |
Emp. Form. | C18H20N2O3 |
Mol. Mass. | 312.363 |
SMILES | CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3CCC4=O)ccc5C(N)=O |r| |
Structure |
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